家蚕丝腺发育与丝蛋白合成的关键调控因子及其作用机制研究进展

Research progress on key regulatory factors and their mechanisms in the development of the silk gland and the synthesis of silk proteins in Bombyx mori

摘要:

家蚕丝腺是合成和分泌丝蛋白的唯一器官，其高效的生物合成能力是蚕丝产业的基础。丝蛋白合成主要涉及丝素蛋白重链（fib-h）、丝素蛋白轻链（fib-l）以及丝胶蛋白（ser1、ser2、ser3）等关键基因，这些基因的表达具有严格的时空特异性。本文概述了Hox基因家族成员（如Antp、Ubx）、POU结构域转录因子、bHLH类转录因子以及BmFoxA（SGF-1）等关键调控因子对丝腺发育与丝蛋白合成的调控进展，旨在深入理解家蚕丝腺高效合成丝蛋白的分子基础，以期为提升蚕丝产量与品质提供理论参考。

Abstract:

The silk gland of Bombyx mori is the sole organ responsible for the synthesis and secretion of silk proteins, and its highly efficient biosynthetic capacity is the foundation of the silk industry. The synthesis of silk proteins mainly involves key genes such as fibroin heavy chain (fib-h), fibroin light chain (fib-l), and sericin proteins (ser1, ser2, ser3), whose expression is strictly spatiotemporally regulated. This article summarizes the progress in the regulation of silk gland development and silk protein synthesis by key regulatory factors such as Hox gene family members (e.g., Antp,Ubx),POU domain transcription factors, bHLH class transcription factors, and BmFoxA (SGF-1), aiming to deepen the understanding of the molecular basis of the highly efficient synthesis of silk proteins in the silk gland of Bombyx mori, and to provide theoretical references for improving the yield and quality of silk.